TEMP
type: Ontology
auto-generated-by: OBO-Edit 2.2
default-namespace: bcteo
has_obo_format_version: 1.1

definition
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

characterizes
type: ObjectProperty
has_obo_namespace: bcteo
id: characterizes

derives_from
type: ObjectProperty
has_obo_namespace: bcteo
id: derives_from

intervenes_in
type: ObjectProperty
has_obo_namespace: bcteo
id: intervenes_in

part_of
type: ObjectProperty
has_obo_namespace: bcteo
id: part_of

Cell seeding
type: Class
subclass of: In vitro study
definition: Phase in which cells are loaded onto a carrier, substrate or threedimensional material.
has_obo_namespace: bcteo
id: ID:0000000

Cell expansion
type: Class
subclass of: In vitro study
definition: Experimental phase aimed to amplify the number of cell in culture, through their doubling.
has_obo_namespace: bcteo
id: ID:0000001

Scaffold property
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Biomaterial
definition: Property that is typical of a specific scaffold, depending not only on the material but even on the shape, the size, the structure etc.
has_obo_namespace: bcteo
id: ID:0000002

Cell
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell seeding
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell expansion
subclass of: Restriction
  on property: intervenes_in
  some values from: Implant
subclass of: Restriction
  on property: part_of
  some values from: Primary cell culture
subclass of: Restriction
  on property: part_of
  some values from: Cell line
definition: Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
has_obo_namespace: caro
id: ID:0000003

Axiom
annotated source: Cell
annotated property: definition
annotated target: Anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
database_cross_reference: CARO:0000013

Mechanical property
type: Class
subclass of: Scaffold property
definition: Property that reveals the reaction, either elastic or plastic, of a metal to an applied stress. Tensile strength, yield strength, elongation, reduction of area, hardness, impact strength, and bend ability are examples of mechanical properties.
has_obo_namespace: bcteo
id: ID:0000004

Cell expansion environment
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell expansion
definition: Experimental environment where cells are expanded. It describes all the biological parameters related to cell expansion.
has_obo_namespace: bcteo
id: ID:0000005

Morphological property
type: Class
subclass of: Scaffold property
definition: Property of materials, biological tissues or other objects, and their specific structural features. It can regard aspects of the outward appearance (shape, structure, pattern) as well as the form and structure of the internal parts.
has_obo_namespace: bcteo
id: ID:0000006

Neoformed tissue
type: Class
subclass of: Tissue
subclass of: Restriction
  on property: derives_from
  some values from: Implant
subclass of: Restriction
  on property: intervenes_in
  some values from: Cellular response evaluation
definition: Tissue grown on substitute material.
has_obo_namespace: bcteo
id: ID:0000007

Primary cell culture
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Isolated tissue
definition: Cell culture where the cells derive from a fresh tissue source.
has_obo_namespace: obi
id: ID:0000008

Axiom
annotated source: Primary cell culture
annotated property: definition
annotated target: Cell culture where the cells derive from a fresh tissue source.
database_cross_reference: OBI:0100061

Density
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Compression test
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
subclass of: Restriction
  on property: derives_from
  some values from: Torsion test
definition: Mass per unit volume.
database_cross_reference: OPB:00546
has_obo_namespace: bcteo
id: ID:0000009

Young's module
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Compression test
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
subclass of: Restriction
  on property: derives_from
  some values from: Torsion test
definition: Measure of the stiffness of an elastic material and is a quantity used to characterize materials. It is defined as the ratio of the stress along an axis over the strain along that axis in the range of stress in which Hooke's law holds.
has_obo_namespace: bcteo
has_related_synonym: Elastic modulus
has_related_synonym: Tensile modulus
id: ID:0000010

Pore shape
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Porosity
definition: The shape of the pores in the material.
has_obo_namespace: bcteo
id: ID:0000011

Ovis aries
type: Class
subclass of: Donor
subclass of: Host
database_cross_reference: NCBITaxon:9940
has_obo_namespace: ncbi_taxonomy
id: ID:0000012

Total porosity
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Porosity
definition: Percentage of pore space.
has_obo_namespace: bcteo
id: ID:0000013

Disk
type: Class
subclass of: Shape
definition: A round, flattened, platelike structure.
has_obo_namespace: bcteo
id: ID:0000014

Resilience
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Compression test
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
subclass of: Restriction
  on property: derives_from
  some values from: Torsion test
definition: Ability of a material to absorb energy when it is deformed elastically, and release that energy upon unloading.
has_obo_namespace: bcteo
id: ID:0000015

Cube
type: Class
subclass of: Shape
definition: A symmetrical three-dimensional shape, either solid or hollow, contained by six equal squares.
has_obo_namespace: bcteo
id: ID:0000016

Porosity
type: Class
subclass of: Morphological property
definition: Measure of the void (i.e., "empty") spaces in a material, and is a fraction of the volume of voids over the total volume, between 0 and 1, or as a percentage between 0 and 100%.
has_obo_namespace: bcteo
id: ID:0000017

Culture medium
type: Class
subclass of: Cell culture environment
definition: Liquid or gel designed to support the growth of microorganisms or cells. There are different types of media for growing different types of cells.
has_obo_namespace: bcteo
id: ID:0000018

Expansion medium
type: Class
subclass of: Cell expansion environment
definition: Liquid or gel designed to expand cells. There are different types of media for culture different types of cells.
has_obo_namespace: bcteo
id: ID:0000019

Cell line
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Isolated tissue
definition: Population of cells cultured in vitro that are descended through one or more generations (and possible sub-cultures) from a single primary culture which was originally derived from part of an organism. The cells of such a population share common characteristics.
has_obo_namespace: ero
id: ID:0000020

Axiom
annotated source: Cell line
annotated property: definition
annotated target: Population of cells cultured in vitro that are descended through one or more generations (and possible sub-cultures) from a single primary culture which was originally derived from part of an organism. The cells of such a population share common characteristics.
database_cross_reference: ERO:0000009

Experiment
type: Class
definition: A methodical procedure carried out with the goal of verifying, falsifying, or establishing the validity of a hypothesis.
has_obo_namespace: bcteo
id: ID:0000021

Size
type: Class
subclass of: Morphological property
definition: The magnitude of a quantity, such as length or mass, relative to a unit of measurement.
has_obo_namespace: bcteo
id: ID:0000022

In vitro study
type: Class
subclass of: Experiment
definition: A study design that is done in a test environment, such as a culture dish, using an established cell culture procedure.
has_obo_namespace: bcteo
has_related_synonym: In vitro study
id: ID:0000023

Axiom
annotated source: In vitro study
annotated property: has_related_synonym
annotated target: In vitro study
database_cross_reference: OBI:0001285

Weight
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Donor
definition: A physical quality inhering in a bearer that has mass near a gravitational body.
has_obo_namespace: pato
id: ID:0000024

Axiom
annotated source: Weight
annotated property: definition
annotated target: A physical quality inhering in a bearer that has mass near a gravitational body.
database_cross_reference: PATO:0000128

Pore volume
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Porosity
definition: The pores in the material considered collectively.
has_obo_namespace: bcteo
id: ID:0000025

Shape
type: Class
subclass of: Morphological property
definition: Geometrical description of the part of that space occupied by the object, as determined by its external boundary, abstracting from location and orientation in space, size, and other properties such as colour, content, and material composition.
has_obo_namespace: bcteo
id: ID:0000026

In vivo study
type: Class
subclass of: Experiment
definition: A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model.
has_obo_namespace: obi
id: ID:0000027

Axiom
annotated source: In vivo study
annotated property: definition
annotated target: A study design that is conducted entirely in a living organism, e.g. a compound treatment in a mouse model.
database_cross_reference: OBI:0001199

Implant
type: Class
subclass of: In vivo study
definition: A medical device manufactured to replace a missing biological structure, support a damaged biological structure, or enhance an existing biological structure.
has_obo_namespace: bcteo
id: ID:0000028

Ectopic implant
type: Class
subclass of: Implant
definition: An substitute material implant out of the original place.
has_obo_namespace: bcteo
id: ID:0000029

Orthotopic implant
type: Class
subclass of: Implant
definition: A substitute material implant in the original place.
has_obo_namespace: bcteo
id: ID:0000030

Connective tissue
type: Class
subclass of: Neoformed tissue
subclass of: Natural tissue
definition: The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former.
has_obo_namespace: bto
id: ID:0000031

Axiom
annotated source: Connective tissue
annotated property: definition
annotated target: The tissue which binds together and is the support of the various structures of the body. It is made up of fibroblasts, fibroglia, collagen fibrils, and elastic fibrils. It is derived from the mesoderm and in a broad sense includes the collagenous, elastic, mucous, reticular, osseous, and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former.
database_cross_reference: BTO:0000421

Other ceramic material
type: Class
subclass of: Ceramic
definition: Ceramic materials not included in the ceramic list.
has_obo_namespace: bcteo
id: ID:0000032

Cellular response evaluation
type: Class
definition: Eveluation of the biochemical, molecular, mechanical events activated within the cell when cultured on a material. The nature of these intracellular events differs according to the type of cell and the considered material.
has_obo_namespace: bcteo
id: ID:0000033

Gender
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Donor
subclass of: Restriction
  on property: characterizes
  some values from: Host
definition: Range of physical, mental, and behavioral characteristics distinguishing between masculinity and femininity.
has_obo_namespace: snomedct
id: ID:0000034

Axiom
annotated source: Gender
annotated property: definition
annotated target: Range of physical, mental, and behavioral characteristics distinguishing between masculinity and femininity.
database_cross_reference: SNOMEDCT:263495000

Biomaterial
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell seeding
subclass of: Restriction
  on property: intervenes_in
  some values from: Implant
definition: A non-drug substance suitable for inclusion in systems which augment or replace the function of bodily tissues or organs.
has_obo_namespace: bcteo
id: ID:0000035

Intrinsic property
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Biomaterial
definition: an essential or inherent property of a system or of a material itself or within. It is independent of how much of the material is present and is independent of the form of the material. Intrinsic properties are dependent mainly on the chemical composition or structure of the material.
has_obo_namespace: bcteo
id: ID:0000036

Physical property
type: Class
subclass of: Intrinsic property
definition: Material's property that can be discerned without changing the chemical identity of the sample and that can be used to characterize matter and energy and their interactions.
has_obo_namespace: bcteo
id: ID:0000037

Chemical property
type: Class
subclass of: Intrinsic property
definition: Material's property that becomes evident during a chemical reaction.
has_obo_namespace: bcteo
id: ID:0000038

Hydrophilicity
type: Class
subclass of: Chemical property
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan gel
subclass of: Restriction
  on property: characterizes
  some values from: Gelatin
subclass of: Restriction
  on property: characterizes
  some values from: Dextran gel
subclass of: Restriction
  on property: characterizes
  some values from: Polyethylene glycol gel
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan-alginate composite
definition: Property of a molecular entity to be attracted to, and tends to be dissolved by, water.
has_obo_namespace: bcteo
id: ID:0000039

Biocompatibility
type: Class
subclass of: Chemical property
subclass of: Restriction
  on property: characterizes
  some values from: Titanium
subclass of: Restriction
  on property: characterizes
  some values from: Alumina
subclass of: Restriction
  on property: characterizes
  some values from: Glass ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass
subclass of: Restriction
  on property: characterizes
  some values from: Tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Calcium oxide
subclass of: Restriction
  on property: characterizes
  some values from: Calcium carbonate
subclass of: Restriction
  on property: characterizes
  some values from: Gypsum
subclass of: Restriction
  on property: characterizes
  some values from: Collagen
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Silicon-substituted tricalcium phosphate and hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Silk
subclass of: Restriction
  on property: characterizes
  some values from: Titanium dioxide
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite-collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: SPCL-Si
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Strontium-hardystonite-gahnite
subclass of: Restriction
  on property: characterizes
  some values from: Baghdadite-polycaprolactone-glass nanoparticle
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass-collagen-phosphatidylserine
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-glycosaminoglycan
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic-chitosan
subclass of: Restriction
  on property: characterizes
  some values from: Magnesium-calcium phosphate
definition: Ability of a material to perform with an appropriate host response in a specific situation.
has_obo_namespace: bcteo
id: ID:0000040

Hydrophobicity
type: Class
subclass of: Chemical property
subclass of: Restriction
  on property: characterizes
  some values from: Titanium
subclass of: Restriction
  on property: characterizes
  some values from: Alumina
subclass of: Restriction
  on property: characterizes
  some values from: Glass ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass
subclass of: Restriction
  on property: characterizes
  some values from: Tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone
subclass of: Restriction
  on property: characterizes
  some values from: Silicon-substituted tricalcium phosphate and hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite-collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: SPCL-Si
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Baghdadite-polycaprolactone-glass nanoparticle
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass-collagen-phosphatidylserine
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-glycosaminoglycan
definition: Property of a molecular entity that is repelled from a mass of water.
has_obo_namespace: bcteo
id: ID:0000041

Resorbability
type: Class
subclass of: Chemical property
subclass of: Restriction
  on property: characterizes
  some values from: Ultra high molecular weight polyethylene
subclass of: Restriction
  on property: characterizes
  some values from: Tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic acid
subclass of: Restriction
  on property: characterizes
  some values from: Calcium oxide
subclass of: Restriction
  on property: characterizes
  some values from: Calcium carbonate
subclass of: Restriction
  on property: characterizes
  some values from: Gypsum
subclass of: Restriction
  on property: characterizes
  some values from: Collagen
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone
subclass of: Restriction
  on property: characterizes
  some values from: Alginate
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan gel
subclass of: Restriction
  on property: characterizes
  some values from: Gelatin
subclass of: Restriction
  on property: characterizes
  some values from: Dextran gel
subclass of: Restriction
  on property: characterizes
  some values from: Polyethylene glycol gel
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan-alginate composite
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-hydroxyapatite composite
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite composite
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-chitosan composite
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-collagen composite
subclass of: Restriction
  on property: characterizes
  some values from: Polyglycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Poloxamine-polylysine acrylate
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Poly-L-lactide
subclass of: Restriction
  on property: characterizes
  some values from: Silicon-substituted tricalcium phosphate and hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Silk
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite-collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: SPCL-Si
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Baghdadite-polycaprolactone-glass nanoparticle
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass-collagen-phosphatidylserine
subclass of: Restriction
  on property: characterizes
  some values from: Polyurethane
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-glycosaminoglycan
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic-chitosan
subclass of: Restriction
  on property: characterizes
  some values from: Magnesium-calcium phosphate
definition: Property of a material that, upon placement within the organism, starts to dissolve (resorbed) and, in some cases, is slowly replaced by advancing tissue (such as bone).
has_obo_namespace: bcteo
id: ID:0000042

Thermal stability
type: Class
subclass of: Physical property
subclass of: Restriction
  on property: characterizes
  some values from: Stainless steel
subclass of: Restriction
  on property: characterizes
  some values from: Titanium
subclass of: Restriction
  on property: characterizes
  some values from: Alumina
subclass of: Restriction
  on property: characterizes
  some values from: Partially stabilised zirconia
subclass of: Restriction
  on property: characterizes
  some values from: Glass ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass
subclass of: Restriction
  on property: characterizes
  some values from: Tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic acid
subclass of: Restriction
  on property: characterizes
  some values from: Calcium oxide
subclass of: Restriction
  on property: characterizes
  some values from: Calcium carbonate
subclass of: Restriction
  on property: characterizes
  some values from: Gypsum
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Polyethylene glycol
subclass of: Restriction
  on property: characterizes
  some values from: Silicon-substituted tricalcium phosphate and hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite-collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic-chitosan
definition: Stability of a molecule at high temperatures.
has_obo_namespace: bcteo
id: ID:0000043

Electrical conductivity
type: Class
subclass of: Physical property
subclass of: Restriction
  on property: characterizes
  some values from: Stainless steel
subclass of: Restriction
  on property: characterizes
  some values from: Titanium
definition: It measures a material's ability to conduct an electric current.
has_obo_namespace: bcteo
id: ID:0000044

Thermal conductivity
type: Class
subclass of: Physical property
subclass of: Restriction
  on property: characterizes
  some values from: Stainless steel
subclass of: Restriction
  on property: characterizes
  some values from: Titanium
definition: Property of a material to conduct heat.
has_obo_namespace: bcteo
id: ID:0000045

Age
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Donor
subclass of: Restriction
  on property: characterizes
  some values from: Host
definition: A temporal measurement of the time period elapsed since an identifiable point in the life cycle of an organism. If a developmental stage is specified, the identifiable point would be the beginning of that stage. Otherwise the identifiable point must be specified such as planting (e.g. 3 days post planting).
has_obo_namespace: mo
id: ID:0000046

Axiom
annotated source: Age
annotated property: definition
annotated target: A temporal measurement of the time period elapsed since an identifiable point in the life cycle of an organism. If a developmental stage is specified, the identifiable point would be the beginning of that stage. Otherwise the identifiable point must be specified such as planting (e.g. 3 days post planting).
database_cross_reference: MO:467

Cell seeding time
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Cell seeding
has_obo_namespace: bcteo
id: ID:0000047

Cell expansion time
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Cell expansion
definition: Duration of the cellular expansion phase.
has_obo_namespace: bcteo
id: ID:0000048

Cell quantity
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Cell seeding
subclass of: Restriction
  on property: characterizes
  some values from: Cell expansion
definition: Amount of used cells.
has_obo_namespace: bcteo
id: ID:0000049

Diameter
type: Class
subclass of: Size
definition: A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.
has_obo_namespace: pato
id: ID:0000050

Axiom
annotated source: Diameter
annotated property: definition
annotated target: A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.
database_cross_reference: PATO:0001334

Pore size
type: Class
subclass of: Size
subclass of: Restriction
  on property: characterizes
  some values from: Porosity
definition: It gives an indication of the median or mean size of the pores on a membrane surface.
has_obo_namespace: bcteo
id: ID:0000051

Mechanics analysis
type: Class
subclass of: Cellular response evaluation
definition: Studies about the mechanical behavior of materials, especially their motion and deformation under the action of forces, temperature changes, phase changes, and other external or internal agents.
has_obo_namespace: bcteo
id: ID:0000052

Pore size distribution
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Porosity
definition: It is the relative abundance of each pore size in a representative volume.
has_obo_namespace: bcteo
id: ID:0000053

Biomolecular analysis
type: Class
subclass of: Cellular response evaluation
definition: Investigation of biomolecules, which are molecules that are involved in the maintenance and metabolic processes of all living organisms.
has_obo_namespace: bcteo
id: ID:0000054

Length
type: Class
subclass of: Size
definition: The measurement of the extent of something along its greatest dimension.
has_obo_namespace: bcteo
id: ID:0000055

Height
type: Class
subclass of: Size
definition: The distance from the base of something to the top.
has_obo_namespace: bcteo
id: ID:0000056

Width
type: Class
subclass of: Size
definition: A piece of material measured along its smaller dimension or its crosswise grain.
has_obo_namespace: bcteo
id: ID:0000057

Cylinder
type: Class
subclass of: Shape
definition: A solid geometric figure with straight parallel sides and a circular or oval section.
has_obo_namespace: bcteo
id: ID:0000058

Sphere
type: Class
subclass of: Shape
definition: A three-dimensional surface, all points of which are equidistant from a fixed point.
has_obo_namespace: bcteo
id: ID:0000059

Atomic Force Microscopy
type: Class
subclass of: Mechanics analysis
subclass of: Morphology analysis
definition: Very high-resolution type of scanning probe microscopy, with demonstrated resolution on the order of fractions of a nanometer, more than 1000 times better than the optical diffraction limit. The information is gathered by "feeling" the surface with a mechanical probe. Piezoelectric elements that facilitate tiny but accurate and precise movements on (electronic) command enable the very precise scanning.
has_obo_namespace: bcteo
has_related_synonym: AFM
id: ID:0000060

Dynamic Mechanical Analysis
type: Class
subclass of: Mechanics analysis
definition: Technique used to study and characterize materials. It is most useful for studying the viscoelastic behavior of polymers. A sinusoidal stress is applied and the strain in the material is measured, allowing one to determine the complex modulus. The temperature of the sample or the frequency of the stress are often varied, leading to variations in the complex modulus. Each test provides a stress-strain curve as output, which describes the relationship between the applied stress and the shown strain for a particular material.
has_obo_namespace: bcteo
has_related_synonym: DMA
id: ID:0000061

X-ray microtomography
type: Class
subclass of: Morphology analysis
definition: Microtomography uses a similar technique as X-ray tomography systems used in medicine (CT Scans) but with much finer resolution. Multiple 2D X-ray images are stored while either the sample or the source / detector pair is rotated. Internal structures are reconstructed as a series of 2D cross sections (up to 2600 in a single scan) which are then used to analyze the two and three dimensional morphological parameters of the object. The process is non destructive and requires no special preparation of the specimen.
has_obo_namespace: bcteo
has_related_synonym: Micro-CT
id: ID:0000062

Real-time polymerase chain reaction
type: Class
subclass of: Biomolecular analysis
definition: A laboratory technique based on the PCR, which is used to amplify and simultaneously quantify a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample.
has_obo_namespace: obi
has_related_synonym: Kinetic polymerase chain reaction
has_related_synonym: Quantitative real time polymerase chain reaction
has_related_synonym: Real Time PCR
has_related_synonym: qPCR
id: ID:0000063

Axiom
annotated source: Real-time polymerase chain reaction
annotated property: definition
annotated target: A laboratory technique based on the PCR, which is used to amplify and simultaneously quantify a specific DNA molecule based on the use of complementary probes/primers. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample.
database_cross_reference: OBI:0000893

Transmission electron microscopy
type: Class
subclass of: Morphology analysis
definition: Microscopy technique whereby a beam of electrons is transmitted through an ultra thin specimen, interacting with the specimen as it passes through. TEMs are capable of imaging at a significantly higher resolution than light microscopes: this enables to examine fine detail. An image is formed from the interaction of the electrons transmitted through the specimen; the image is magnified and focused onto an imaging device, such as a fluorescent screen, on a layer of photographic film, or to be detected by a sensor such as a CCD camera.
has_obo_namespace: bcteo
has_related_synonym: TEM
id: ID:0000064

Gene expression microarray
type: Class
subclass of: Biomolecular analysis
definition: Gene expression microarray technology measures the relative activity of previously identified target genes and provide the gene expression profiling, which is the measurement, at once, of the activation of thousands of genes, to create a global picture of cellular function.
has_obo_namespace: bcteo
has_related_synonym: DNA microarray
id: ID:0000065

Axiom
annotated source: Gene expression microarray
annotated property: has_related_synonym
annotated target: DNA microarray
database_cross_reference: OBI:0400148

Mass Spectrometry
type: Class
subclass of: Biomolecular analysis
definition: Measuring method consisting of turning elements in a sample into ions, isolating them according to the ratio between the mass and charge numbers and detecting it electrically.
database_cross_reference: PRIDE:0000027
has_obo_namespace: obi
id: ID:0000066

Axiom
annotated source: Mass Spectrometry
annotated property: definition
annotated target: Measuring method consisting of turning elements in a sample into ions, isolating them according to the ratio between the mass and charge numbers and detecting it electrically.
database_cross_reference: OBI:0000470

Immunohistofluorescence
type: Class
subclass of: Biomolecular analysis
definition: Histofluorescence (fluorescence of the tissues under exposure to ultraviolet rays following the injection of a fluorescent substance or as a result of a natural fluorescing substance) accomplished by injection of antibody labeled with fluorochrome.
has_obo_namespace: bcteo
has_related_synonym: IHF
id: ID:0000067

Histochemical staining
type: Class
subclass of: Morphology analysis
definition: study of the microscopic anatomy of cells and tissues of plants and animals. It is commonly performed by examining cells and tissues by sectioning and staining, followed by examination under a light microscope or electron microscope. Histological studies may be conducted via tissue culture, where live cells can be isolated and maintained in a proper environment outside the body for various research projects. The ability to visualize or differentially identify microscopic structures is frequently enhanced through the use of histological stains.
database_cross_reference: OBI:0600020
has_obo_namespace: bcteo
id: ID:0000068

the visual examination of cells or tissue (or images of them) with an assessment regarding a quality of the cells or tissue. Parts are: staining, imaging, judgement
type: Axiom
annotated source: Histochemical staining
annotated property: database_cross_reference
annotated target: OBI:0600020

Immunohistochemistry
type: Class
subclass of: Biomolecular analysis
definition: Method using an antibody coupled with some colouring agent to detect a specific protein within a tissue sample. In some cases the primary antibody is directly linked to a colouring agent, more often the primary antibody is targeted by a secondary antibody, targeting the primary antibody.
has_obo_namespace: mi
has_related_synonym: IHC
id: ID:0000069

Axiom
annotated source: Immunohistochemistry
annotated property: definition
annotated target: Method using an antibody coupled with some colouring agent to detect a specific protein within a tissue sample. In some cases the primary antibody is directly linked to a colouring agent, more often the primary antibody is targeted by a secondary antibody, targeting the primary antibody.
database_cross_reference: MI:1198

Scanning electron microscopy
type: Class
subclass of: Morphology analysis
definition: Electron microscope that produces images of a sample by scanning it with a focused beam of electrons. The electrons interact with electrons in the sample, producing various signals that can be detected and that contain information about the sample's surface topography and composition. The electron beam is generally scanned in a raster scan pattern, and the beam's position is combined with the detected signal to produce an image. SEM can achieve resolution better than 1 nanometer.
has_obo_namespace: bcteo
has_related_synonym: SEM
id: ID:0000070

Morphology analysis
type: Class
subclass of: Cellular response evaluation
definition: Investigations about the form and structure of organisms and their specific features.
has_obo_namespace: bcteo
id: ID:0000071

Chondrocyte
type: Class
subclass of: Cell
definition: Cartilage cells. They make the structural components of cartilage.
has_obo_namespace: bto
id: ID:0000072

Axiom
annotated source: Chondrocyte
annotated property: definition
annotated target: Cartilage cells. They make the structural components of cartilage.
database_cross_reference: BTO:0000249

Osteoblast
type: Class
subclass of: Cell
definition: Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.
has_obo_namespace: cl
id: ID:0000073

Axiom
annotated source: Osteoblast
annotated property: definition
annotated target: Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.
database_cross_reference: CL:0000062

Mesenchymal stem cell
type: Class
subclass of: Cell
definition: A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues.
has_obo_namespace: bto
has_related_synonym: MSC
id: ID:0000074

Axiom
annotated source: Mesenchymal stem cell
annotated property: definition
annotated target: A special adult stem cell, which is a multipotent stem cell, that can be found in bone marrow and can produce all cell types of bone, cartilage, fat, blood, and connective tissues.
database_cross_reference: BTO:0003298

Organism
type: Class
definition: A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
has_obo_namespace: obi
id: ID:0000075

Axiom
annotated source: Organism
annotated property: definition
annotated target: A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.
database_cross_reference: OBI:0100026

Cell concentration
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Cell seeding
subclass of: Restriction
  on property: characterizes
  some values from: Cell expansion
definition: Amount of cells per volume of medium used.
has_obo_namespace: bcteo
id: ID:0000076

Affymetrix technology
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Gene expression microarray
definition: Affymetrix is a US company that manufactures DNA microarrays.
has_obo_namespace: bcteo
id: ID:0000077

Implant time
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Implant
definition: Time when the substitue material is within the host.
has_obo_namespace: bcteo
id: ID:0000078

Cartilage
type: Class
subclass of: Connective tissue
subclass of: Isolated tissue
definition: A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body.
has_obo_namespace: bto
id: ID:0000079

Axiom
annotated source: Cartilage
annotated property: definition
annotated target: A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body.
database_cross_reference: BTO:0000206

Bone marrow
type: Class
subclass of: Isolated tissue
definition: The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.
database_cross_reference: BTO:0000141
has_obo_namespace: bto
id: ID:0000080

Axiom
annotated source: Bone marrow
annotated property: definition
annotated target: The soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.
database_cross_reference: BTO:0000141

Adipose tissue
type: Class
subclass of: Isolated tissue
definition: Connective tissue in which fat is stored and which has the cells distended by droplets of fat.
database_cross_reference: BTO:0001487
has_obo_namespace: bto
id: ID:0000081

Axiom
annotated source: Adipose tissue
annotated property: definition
annotated target: Connective tissue in which fat is stored and which has the cells distended by droplets of fat.
database_cross_reference: BTO:0001487

Donor
type: Class
subclass of: Organism
definition: A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro.
has_obo_namespace: obi
id: ID:0000082

Axiom
annotated source: Donor
annotated property: definition
annotated target: A role which inheres in an organism or part thereof from which any part including cell, organ or tissue is removed with the intention that the donated part will be placed into another organism and/or cultured in vitro.
database_cross_reference: OBI:1110087

Host
type: Class
subclass of: Organism
subclass of: Restriction
  on property: intervenes_in
  some values from: Implant
definition: Organism for the implant.
has_obo_namespace: bcteo
id: ID:0000083

Gel
type: Class
subclass of: Biomaterial
definition: Solid, jelly-like material that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state. By weight, gels are mostly liquid, yet they behave like solids due to a three-dimensional cross-linked network within the liquid. It is the crosslinking within the fluid that give a gel its structure (hardness) and contribute to the adhesive stick.
has_obo_namespace: bcteo
id: ID:0000084

Other metal material
type: Class
subclass of: Metal
definition: Metal materials not included in the previous list.
has_obo_namespace: bcteo
id: ID:0000085

Stainless steel
type: Class
subclass of: Metal
definition: Steel alloy with a minimum of 10.5%[1] to 11% chromium content by mass. It does not readily corrode, rust or stain with water as ordinary steel does, but despite the name it is not fully stain-proof, most notably under low oxygen, high salinity, or poor circulation environments.
has_obo_namespace: bcteo
has_related_synonym: Inox
has_related_synonym: Inox steel
id: ID:0000086

Other polymeric materials
type: Class
subclass of: Polymer
definition: Other polymeric materials not included in the previous list.
has_obo_namespace: bcteo
id: ID:0000087

Liquid Chromatography-Mass Spectrometry
type: Class
subclass of: Mass Spectrometry
definition: Hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
has_obo_namespace: nci_thesaurus
has_related_synonym: LC/MS
id: ID:0000088

Axiom
annotated source: Liquid Chromatography-Mass Spectrometry
annotated property: definition
annotated target: Hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics.
database_cross_reference: Thesaurus:Liquid_Chromatography_Mass_Spectrometry

Titanium
type: Class
subclass of: Metal
definition: Chemical element with symbol Ti and atomic number 22. It has a low density and is a strong, lustrous, corrosion-resistant (including sea water, aqua regia and chlorine) transition metal with a silver color.
has_obo_namespace: bcteo
id: ID:0000089

Alumina
type: Class
subclass of: Ceramic
definition: Chemical compound of aluminium and oxygen with the chemical formula Al2O3.
has_obo_namespace: bcteo
has_related_synonym: Aloxide
has_related_synonym: Aluminium oxide
id: ID:0000090

Partially stabilised zirconia
type: Class
subclass of: Other biomaterials
definition: Non-metallic structural material that combines hardness, reduced fragility, and chemical inertness with high chemical stability in aggressive environments throughout a wide temperature range.
has_obo_namespace: bcteo
id: ID:0000091

Ultra high molecular weight polyethylene
type: Class
subclass of: Polymer
definition: Subset of the thermoplastic polyethylene, characterized by extremely long chains, with a molecular weight usually between 2 and 6 million. The longer chain serves to transfer load more effectively to the polymer backbone by strengthening intermolecular interactions.
has_obo_namespace: bcteo
has_related_synonym: HMPE
has_related_synonym: HPPE
has_related_synonym: High-modulus polyethylene
has_related_synonym: High-performance polyethylene
has_related_synonym: UHMW
has_related_synonym: UHMWPE
id: ID:0000092

Other gel
type: Class
subclass of: Gel
definition: Gel material not listed among the gels.
has_obo_namespace: bcteo
id: ID:0000093

Glass ceramic
type: Class
subclass of: Ceramic
definition: Polycrystalline material produced through controlled crystallization of base glass.
has_obo_namespace: bcteo
id: ID:0000094

Bioglass
type: Class
subclass of: Ceramic
definition: Family of bioactive glasses, composed of SiO2, Na2O, CaO and P2O5 in specific proportions.
has_obo_namespace: bcteo
id: ID:0000095

Tricalcium phosphate
type: Class
subclass of: Ceramic
definition: Calcium salt of phosphoric acid with the chemical formula Ca3(PO4)2.
has_obo_namespace: bcteo
has_related_synonym: BPL
has_related_synonym: Bone phosphate of lime
has_related_synonym: Tribasic calcium phosphate
id: ID:0000096

Polylactic acid
type: Class
subclass of: Polymer
definition: Athermoplastic aliphatic polyester derived from renewable resources.
has_obo_namespace: bcteo
has_related_synonym: PLA
has_related_synonym: Polylactide
id: ID:0000097

Calcium oxide
type: Class
subclass of: Ceramic
definition: Chemical compound with the formula CaO.
has_obo_namespace: bcteo
has_related_synonym: Burnt lime
has_related_synonym: Quicklime
id: ID:0000098

Calcium carbonate
type: Class
subclass of: Ceramic
definition: Chemical compound with the formula CaCO3.
has_obo_namespace: bcteo
id: ID:0000099

Gypsum
type: Class
subclass of: Ceramic
definition: Very soft sulfate mineral composed of calcium sulfate dihydrate, with the chemical formula CaSO4·2H2O.
has_obo_namespace: bcteo
id: ID:0000100

Growth environment
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell seeding
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell expansion
subclass of: Restriction
  on property: intervenes_in
  some values from: Implant
definition: The collection of material entities and their qualities that are located near a live organism, tissue or cell and can influence its growth.
has_obo_namespace: obi
id: ID:0000101

Axiom
annotated source: Growth environment
annotated property: definition
annotated target: The collection of material entities and their qualities that are located near a live organism, tissue or cell and can influence its growth.
database_cross_reference: OBI:0000997

Tissue
type: Class
definition: Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships.
has_obo_namespace: caro
id: ID:0000102

Axiom
annotated source: Tissue
annotated property: definition
annotated target: Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships.
database_cross_reference: CARO:0000043

Natural tissue
type: Class
subclass of: Tissue
subclass of: Restriction
  on property: part_of
  some values from: Organism
definition: Natural tissue located within the organism in the natural site.
has_obo_namespace: bcteo
id: ID:0000103

Isolated tissue
type: Class
subclass of: Tissue
definition: Tissue that has been extracted from the organism.
has_obo_namespace: bcteo
id: ID:0000104

Bone
type: Class
subclass of: Connective tissue
definition: The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone.
has_obo_namespace: bto
id: ID:0000105

Axiom
annotated source: Bone
annotated property: definition
annotated target: The hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral, component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate (85 per cent) and calcium carbonate (10 per cent), which imparts the quality of rigidity to bone.
database_cross_reference: BTO:0000140

Homo sapiens
type: Class
subclass of: Donor
database_cross_reference: NCBITaxon:9606
has_obo_namespace: ncbi_taxonomy
id: ID:0000106

Mus musculus
type: Class
subclass of: Donor
subclass of: Host
database_cross_reference: NCBITaxon:10090
has_obo_namespace: ncbi_taxonomy
id: ID:0000107

Rattus norvegicus
type: Class
subclass of: Donor
subclass of: Host
database_cross_reference: NCBITaxon:10116
has_obo_namespace: ncbi_taxonomy
id: ID:0000108

Oryctolagus cuniculus
type: Class
subclass of: Donor
subclass of: Host
database_cross_reference: NCBITaxon:9986
has_obo_namespace: ncbi_taxonomy
id: ID:0000109

Bos taurus
type: Class
subclass of: Donor
database_cross_reference: NCBITaxon:9913
has_obo_namespace: ncbi_taxonomy
id: ID:0000110

Capra aegagrus hircus
type: Class
subclass of: Host
database_cross_reference: NCBITaxon:9925
has_obo_namespace: ncbi_taxonomy
id: ID:0000111

Weight
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Host
definition: A physical quality inhering in a bearer that has mass near a gravitational body.
has_obo_namespace: pato
id: ID:0000112

Axiom
annotated source: Weight
annotated property: definition
annotated target: A physical quality inhering in a bearer that has mass near a gravitational body.
database_cross_reference: PATO:0000128

Collagen
type: Class
subclass of: Polymer
definition: Group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of vertebrates. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content.
has_obo_namespace: bcteo
id: ID:0000113

Chitosan
type: Class
subclass of: Polymer
definition: An aminoglycan consisting of beta-(1->4)-linked D-glucosamine residues.
has_obo_namespace: chebi
id: ID:0000114

Axiom
annotated source: Chitosan
annotated property: definition
annotated target: An aminoglycan consisting of beta-(1->4)-linked D-glucosamine residues.
database_cross_reference: CHEBI:16261

Ceramic
type: Class
subclass of: Biomaterial
definition: Inorganic, nonmetallic solid prepared by the action of heat and subsequent cooling.
has_obo_namespace: bcteo
id: ID:0000115

Calcium-phosphate based ceramic
type: Class
subclass of: Ceramic
definition: Name given to a family of minerals containing calcium ions (Ca2+) together with orthophosphates (PO43-)
has_obo_namespace: bcteo
id: ID:0000116

Metal
type: Class
subclass of: Biomaterial
definition: Element, compound, or alloy that is a good conductor of both electricity and heat. Metals are usually shiny, malleable and ductile.
has_obo_namespace: bcteo
id: ID:0000117

Affymetrix chip
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Affymetrix technology
definition: A nucleic acid microarray assay that uses the GeneChip System as the platform for analyzing complex genetic information.
has_obo_namespace: ero
id: ID:0000118

Axiom
annotated source: Affymetrix chip
annotated property: definition
annotated target: A nucleic acid microarray assay that uses the GeneChip System as the platform for analyzing complex genetic information.
database_cross_reference: ERO:0001265

Polymer
type: Class
subclass of: Biomaterial
definition: A mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.
has_obo_namespace: chebi
id: ID:0000119

Axiom
annotated source: Polymer
annotated property: definition
annotated target: A mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.
database_cross_reference: CHEBI:60027

Bioactivity
type: Class
subclass of: Chemical property
subclass of: Restriction
  on property: characterizes
  some values from: Glass ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Bioglass
subclass of: Restriction
  on property: characterizes
  some values from: Tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic
subclass of: Restriction
  on property: characterizes
  some values from: Hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-hydroxyapatite composite
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite composite
subclass of: Restriction
  on property: characterizes
  some values from: Silicon-substituted tricalcium phosphate and hydroxyapatite
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite-collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: Strontium-hardystonite-gahnite
subclass of: Restriction
  on property: characterizes
  some values from: Calcium-phosphate based ceramic-chitosan
definition: The effect/reaction/interaction/response of a given agent, such as a biomaterial or drug, upon a living organism or on living tissue.
has_obo_namespace: bcteo
id: ID:0000120

Bioinertness
type: Class
subclass of: Chemical property
subclass of: Restriction
  on property: characterizes
  some values from: Stainless steel
subclass of: Restriction
  on property: characterizes
  some values from: Alumina
subclass of: Restriction
  on property: characterizes
  some values from: Partially stabilised zirconia
subclass of: Restriction
  on property: characterizes
  some values from: Ultra high molecular weight polyethylene
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone
subclass of: Restriction
  on property: characterizes
  some values from: Polyethylene glycol
subclass of: Restriction
  on property: characterizes
  some values from: Alginate
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan gel
subclass of: Restriction
  on property: characterizes
  some values from: Gelatin
subclass of: Restriction
  on property: characterizes
  some values from: Dextran gel
subclass of: Restriction
  on property: characterizes
  some values from: Polyethylene glycol gel
subclass of: Restriction
  on property: characterizes
  some values from: Chitosan-alginate composite
subclass of: Restriction
  on property: characterizes
  some values from: Polyglycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Poloxamine-polylysine acrylate
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Poly-L-lactide
subclass of: Restriction
  on property: characterizes
  some values from: SPCL-Si
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Baghdadite-polycaprolactone-glass nanoparticle
definition: It refers to any material that once placed in the human body has minimal interaction with its surrounding tissue. Generally a fibrous capsule might form around bioinert implants hence its biofunctionality relies on tissue integration through the implant.
has_obo_namespace: bcteo
id: ID:0000121

Ultimate tensile strength
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
definition: Maximum stress that a material can withstand while being stretched or pulled before failing or breaking.
has_obo_namespace: bcteo
has_related_synonym: UTS
has_related_synonym: TS
has_related_synonym: Tensile strength
has_related_synonym: Ultimate strength
id: ID:0000122

Bulk modulus
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Compression test
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
subclass of: Restriction
  on property: derives_from
  some values from: Torsion test
definition: It measures the substance's resistance to uniform compression. It is defined as the ratio of the infinitesimal pressure increase to the resulting relative decrease of the volume.
has_obo_namespace: bcteo
id: ID:0000123

Affymetrix protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Affymetrix technology
definition: The Affymetrix protocol first steps are RNA isolation and conversion to cDNA and cRNA. The RNA is then hybridized with the array probes (25-mer) and the unbound material washed away. Finally a signal amplifying reaction is performed, the microarray chip is ready to be scanned and the signal acquired.
has_obo_namespace: bcteo
id: ID:0000124

Affymetrix raw data file
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Affymetrix technology
definition: DAT files contain raw image data; CEL files contain information about the expression levels of the individual probes; CHP files contain information about probe sets; EXP files contain information about experimental conditions and protocols. The CEL file (the most important for analysis) contains information about where each probe is on the chip, an intensity value, standard deviation of the intensity, the number of pixels used to calculate the intensity value, a flag to indicate an outlier as calculated by the algorithm and a user defined flag indicating the feature should be excluded from future analysis.
has_obo_namespace: bcteo
id: ID:0000125

Illumina technology
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Gene expression microarray
definition: Illumina, Inc. is a US company that develops, manufactures and markets integrated systems for the analysis of genetic variation and biological function.
has_obo_namespace: bcteo
id: ID:0000126

Illumina chip
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Illumina technology
definition: In Illumina's BeadArray Technology each bead is covered with hundreds of thousands of copies of a specific oligonucleotide that act as the capture sequences in one of Illumina's assays. Examples are MouseWG-6 v2.0 Expression BeadChip, HumanWG-6 Expression BeadChip.
has_obo_namespace: bcteo
id: ID:0000127

Illumina raw data file
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Illumina technology
definition: Illumina BeadChip gene expression summary file contains the expression levels for each bead type on the arrays on the BeadChip.
has_obo_namespace: bcteo
id: ID:0000128

Other gene expression microarray technologies
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Gene expression microarray
definition: Other gene expression microarray techniques not included in the previous list.
has_obo_namespace: bcteo
id: ID:0000129

Toluidine blue stain
type: Class
subclass of: Histochemical staining
definition: It stains nucleic acids blue and polysaccharides purple.
database_cross_reference: FBbi:00000049
has_obo_namespace: bcteo
id: ID:0000130

Alcian blue stains
type: Class
subclass of: Histochemical staining
definition: Family of polyvalent basic dyes used to stain acidic polysaccharides such as glycosaminoglycans in cartilages and other body structures, some types of mucopolysaccharides, sialylated glycocalyx of cells etc.
database_cross_reference: NDF-RT:N0000166971
has_obo_namespace: bcteo
id: ID:0000131

Masson's trichrome stain
type: Class
subclass of: Histochemical staining
definition: Three-colour staining protocol able to distinguish cells from surrounding connective tissue. Most recipes produce red keratin and muscle fibers, blue or green collagen and bone, light red or pink cytoplasm, and dark brown to black cell nuclei.
has_obo_namespace: bcteo
id: ID:0000132

Other stain
type: Class
subclass of: Histochemical staining
definition: Staining methods not listed before.
has_obo_namespace: bcteo
id: ID:0000133

Contact mode technique
type: Class
subclass of: Atomic Force Microscopy
definition: Static mode operation where the static tip deflection is used as a feedback signal. The force between the tip and the surface is kept constant during scanning by maintaining a constant deflection.
has_obo_namespace: bcteo
id: ID:0000134

Non-contact mode technique
type: Class
subclass of: Atomic Force Microscopy
definition: The tip of the cantilever does not contact the sample surface. The van der Waals forces, which are strongest from 1 nm to 10 nm above the surface, or any other long range force which extends above the surface acts to decrease the resonance frequency of the cantilever. The absence of repulsive forces permits its use in the imaging of soft samples and does not require conducting samples.
has_obo_namespace: bcteo
id: ID:0000135

Tapping mode technique
type: Class
subclass of: Atomic Force Microscopy
definition: The cantilever is driven to oscillate up and down at near its resonance frequency by a small piezoelectric element mounted in the AFM tip holder similar to non-contact mode. However, the amplitude of this oscillation is greater than 10 nm, typically 100 to 200 nm. The interaction of forces acting on the cantilever when the tip comes close to the surface, Van der Waals forces, dipole-dipole interactions, electrostatic forces, etc. cause the amplitude of this oscillation to decrease as the tip gets closer to the sample.
has_obo_namespace: bcteo
id: ID:0000136

Compression test
type: Class
subclass of: Dynamic Mechanical Analysis
definition: Mechanical test where balanced inward ("pushing") forces are applied to different points of a material or structure. Applied forces have no net sum or torque directed. By inducing compression, mechanical properties such as compressive strength or modulus of elasticity, can be measured.
has_obo_namespace: bcteo
id: ID:0000137

Tensile test
type: Class
subclass of: Dynamic Mechanical Analysis
definition: Materials science test in which a sample is subjected to a controlled tension until failure. Properties that are directly measured via a tensile test are ultimate tensile strength, maximum elongation and reduction in area. From these measurements the following properties can also be determined: Young's modulus, Poisson's ratio, yield strength, and strain-hardening characteristics
has_obo_namespace: bcteo
id: ID:0000138

Fracture test
type: Class
subclass of: Dynamic Mechanical Analysis
definition: Used to define a material's ability to resist deformation under load.
has_obo_namespace: bcteo
id: ID:0000139

Torsion test
type: Class
subclass of: Dynamic Mechanical Analysis
definition: Mechanical test where an applied torque generate a twisting of the material.
has_obo_namespace: bcteo
id: ID:0000140

Other mechanical test
type: Class
subclass of: Dynamic Mechanical Analysis
definition: Test not included in the previous list.
has_obo_namespace: bcteo
id: ID:0000141

Illumina protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Illumina technology
definition: The Illumina Gene Expression microarray system uses total RNA as starting material (minimum of 250ng of total RNA at a minimum concentration of 25ng/ul). RNA isolation, cDNA synthesis, and in vitro transcription amplification are followed by hybridization on 50-mer probe sequences (several hundred thou- sand copies of the probe across the bead surface).
has_obo_namespace: bcteo
id: ID:0000142

Direct detection method protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistofluorescence
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistochemistry
definition: The direct method is a one-step staining method and involves a labeled antibody (e.g. FITC-conjugated antiserum) reacting directly with the antigen in tissue sections. While this technique utilizes only one antibody and therefore is simple and rapid, the sensitivity is lower due to little signal amplification, such as with indirect methods, and is less commonly used than indirect methods.
has_obo_namespace: bcteo
id: ID:0000143

Indirect detection method protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistofluorescence
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistochemistry
definition: The indirect method involves an unlabeled primary antibody (first layer) that binds to the target antigen in the tissue and a labeled secondary antibody (second layer) that reacts with the primary antibody. The secondary antibody must be raised against the IgG of the animal species in which the primary antibody has been raised. This method is more sensitive than direct detection strategies because of signal amplification due to the binding of several secondary antibodies to each primary antibody if the secondary antibody is conjugated to the fluorescent or enzyme reporter.
has_obo_namespace: bcteo
id: ID:0000144

Formalin fixed paraffin embedded (FFPE) protocol
type: Class
subclass of: Isolated tissue
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistofluorescence
subclass of: Restriction
  on property: intervenes_in
  some values from: Histochemical staining
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistochemistry
definition: Tissue fixation in formalin (an aqueous solution containing formaldehyde) in order to prevent it from decaying or degeneration and to examine it clearly under a microscope for histological, pathological or cytological studies. The fixed tissue is then embedded in paraffin wax in order to solidify it and easily cut its fine sections.
has_obo_namespace: bcteo
id: ID:0000145

Hematoxylin-eosin stain
type: Class
subclass of: Histochemical staining
definition: A histology technique that involves the staining of cells with a blue nuclear stain, hemalum followed by counterstaining with eosin, which stains eosinophilic structures in various shades of red, pink and orange.
has_obo_namespace: ero
id: ID:0000146

Axiom
annotated source: Hematoxylin-eosin stain
annotated property: definition
annotated target: A histology technique that involves the staining of cells with a blue nuclear stain, hemalum followed by counterstaining with eosin, which stains eosinophilic structures in various shades of red, pink and orange.
database_cross_reference: ERO:0001605

Antibody
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistofluorescence
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistochemistry
definition: An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
has_obo_namespace: go
id: ID:0000147

Axiom
annotated source: Antibody
annotated property: definition
annotated target: An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
database_cross_reference: GO:0042571

Histochemistry stained tissue
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Histochemical staining
definition: Stained tissue are studied to define and examine: bulk tissues (for example muscle fibers or connective tissue), cell populations (i.e. different blood cells), or molecules within individual cells (for example DNA, proteins, lipids, carbohydrates).
has_obo_namespace: bcteo
id: ID:0000148

Immunohistochemistry stained tissue
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Immunohistochemistry
definition: Biological staining is used to mark cells in flow cytometry, and to flag proteins or nucleic acids in tissues. Examples of proteins examined with this technique are BSP, Col I, Col II.
has_obo_namespace: bcteo
id: ID:0000149

Hydroxyapatite
type: Class
subclass of: Ceramic
definition: Naturally occurring mineral form of calcium apatite with the formula Ca5(PO4)3(OH). Up to 50% of bone by weight is a modified form of hydroxyapatite (known as bone mineral).
has_obo_namespace: bcteo
has_related_synonym: HA
has_related_synonym: Hydroxylapatite
has_related_synonym: Synthetic hydroxyapatite
id: ID:0000150

Tandem Mass Spectrometry
type: Class
subclass of: Mass Spectrometry
definition: Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times.
has_obo_namespace: nci_thesaurus
has_related_synonym: MS/MS
id: ID:0000151

Axiom
annotated source: Tandem Mass Spectrometry
annotated property: definition
annotated target: Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times.
database_cross_reference: Thesaurus:Tandem_Mass_Spectrometry

Mass spectra file
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Mass Spectrometry
definition: MS/MS output file containing mass spectra, which show peaks due to the masses of the various ions produced by the fragmentation process. Spectra are converted into peptide sequence tags, used to identify a peptide in a protein database.
has_obo_namespace: bcteo
id: ID:0000152

Mass spectrometry sample preparation protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Mass Spectrometry
definition: The protocol depends on the ion source different requirements for volume, concentration, and composition of the analyte solution. Furthermore, in protein mass spectrometry usually the protein of interest is cleaved into peptides before analysis, either by in-gel digestion or by proteolysis in solution.
has_obo_namespace: bcteo
id: ID:0000153

Composite
type: Class
subclass of: Biomaterial
definition: Materials made from two or more constituent materials with significantly different physical or chemical properties, that when combined, produce a material with characteristics different from the individual components. The individual components remain separate and distinct within the finished structure.
has_obo_namespace: bcteo
id: ID:0000154

Fibroblast
type: Class
subclass of: Cell
definition: A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
has_obo_namespace: cl
id: ID:0000155

Axiom
annotated source: Fibroblast
annotated property: definition
annotated target: A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
database_cross_reference: CL:0000057

Primer
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Real-time polymerase chain reaction
definition: Nucleic acid reagent that is a short strand of nucleic acid that serves as a starting point for DNA or RNA synthesis.
has_obo_namespace: ero
id: ID:0000156

Axiom
annotated source: Primer
annotated property: definition
annotated target: Nucleic acid reagent that is a short strand of nucleic acid that serves as a starting point for DNA or RNA synthesis.
database_cross_reference: ERO:0000631

Quantification file
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Real-time polymerase chain reaction
definition: Quantification can be relative or absolute. Relative quantification is based on internal reference genes to determine fold-differences in expression of the target gene. Absolute quantification gives the exact number of target DNA molecules by comparison with DNA standards. Examples of genes examined with this technique are COL1A1, COL2A1.
has_obo_namespace: bcteo
id: ID:0000157

DNA-polymerase
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Real-time polymerase chain reaction
definition: Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA.
has_obo_namespace: nci_thesaurus
id: ID:0000158

Axiom
annotated source: DNA-polymerase
annotated property: definition
annotated target: Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA.
database_cross_reference: Thesaurus:DNA_Polymerase

Immunoblotting
type: Class
subclass of: Biomolecular analysis
definition: Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
has_obo_namespace: msh
id: ID:0000159

Axiom
annotated source: Immunoblotting
annotated property: definition
annotated target: Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
database_cross_reference: MSH:D015151

Electrophoresis gel
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunoblotting
definition: A gel matrix through which molecules are separated, usually by size or charge, under the influence of an electrical field.
has_obo_namespace: nci_thesaurus
id: ID:0000160

Axiom
annotated source: Electrophoresis gel
annotated property: definition
annotated target: A gel matrix through which molecules are separated, usually by size or charge, under the influence of an electrical field.
database_cross_reference: Thesaurus:Electrophoresis_Gel

Western blot
type: Class
subclass of: Immunoblotting
definition: Procedure to identify and quantify proteins. A mixture of protein is first submitted to an electrophoresis in denaturing condition and then electro-transferred from the gel to a membrane. The membrane is then incubated with a primary antibody specific for a given protein or a specific residue modification in the sample under analysis. A secondary antibody, radiolabelled or fused to fluorophore or to a chromogenic enzyme, targets the first antibody and allows the visualisation of the protein band on the membrane.
has_obo_namespace: mi
id: ID:0000161

Axiom
annotated source: Western blot
annotated property: definition
annotated target: Procedure to identify and quantify proteins. A mixture of protein is first submitted to an electrophoresis in denaturing condition and then electro-transferred from the gel to a membrane. The membrane is then incubated with a primary antibody specific for a given protein or a specific residue modification in the sample under analysis. A secondary antibody, radiolabelled or fused to fluorophore or to a chromogenic enzyme, targets the first antibody and allows the visualisation of the protein band on the membrane.
database_cross_reference: MI:0113

Northern blot
type: Class
subclass of: Immunoblotting
definition: A multistep process in which a mixture of RNA is separated by gel electrophoresis, that is, separation of ionic solutes based on differences in rate of migration in an applied electric field using a semisolid colloid such as agarose or acrylamide as the support medium, followed by transfer to a membrane such as nitrocellulose or nylon and detection of specific RNAs by hybridization of a tagged or labelled polynucleotide, usually a single DNA fragment with a specific, known sequence.
has_obo_namespace: mmo
id: ID:0000162

Axiom
annotated source: Northern blot
annotated property: definition
annotated target: A multistep process in which a mixture of RNA is separated by gel electrophoresis, that is, separation of ionic solutes based on differences in rate of migration in an applied electric field using a semisolid colloid such as agarose or acrylamide as the support medium, followed by transfer to a membrane such as nitrocellulose or nylon and detection of specific RNAs by hybridization of a tagged or labelled polynucleotide, usually a single DNA fragment with a specific, known sequence.
database_cross_reference: MMO:0000339

Southern blot
type: Class
subclass of: Immunoblotting
definition: A standard procedure to identify DNA fragments containing specific gene sequences. In this procedure i) a genome is fragmented using a restriction enzyme ii) the generated fragments are separated by electrophoresis iii) the fragments are transferred to a membrane iv)the membrane is incubated with a radio labelled probe that hybridises any complementary subsequence.
has_obo_namespace: mi
id: ID:0000163

Axiom
annotated source: Southern blot
annotated property: definition
annotated target: A standard procedure to identify DNA fragments containing specific gene sequences. In this procedure i) a genome is fragmented using a restriction enzyme ii) the generated fragments are separated by electrophoresis iii) the fragments are transferred to a membrane iv)the membrane is incubated with a radio labelled probe that hybridises any complementary subsequence.
database_cross_reference: MI:0103

Agarose gel image
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Immunoblotting
definition: Image of the matrix gel containing the separated target molecules (proteins or nucleic acids).
has_obo_namespace: bcteo
id: ID:0000164

Staining protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Histochemical staining
definition: Any of the various methods that use a dye, reagent, or other material for producing coloration in tissues or microorganisms for microscopic examination.
has_obo_namespace: pdq
id: ID:0000165

Axiom
annotated source: Staining protocol
annotated property: definition
annotated target: Any of the various methods that use a dye, reagent, or other material for producing coloration in tissues or microorganisms for microscopic examination.
database_cross_reference: PDQ:CDR0000575401

Immunohistofluorescence stained tissue
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Immunohistofluorescence
definition: Tissues that, under exposure to ultraviolet rays, produce fluorescence. Examples of proteins examined with this technique are BSP, Col I, Col II.
has_obo_namespace: bcteo
id: ID:0000166

Polycaprolactone
type: Class
subclass of: Polymer
definition: Biodegradable polyester prepared by ring opening polymerization of caprolactone using a catalyst such as stannous octoate.
has_obo_namespace: bcteo
has_related_synonym: PCL
id: ID:0000167

AFM image
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Atomic Force Microscopy
definition: High-resolution image acquired from AFM technology. It shows a combination of surface (topological information about the roughness and the features of the surface is derived) and mechanical information, by means of the cantilever which measures the elasticity of the tested sample.
has_obo_namespace: bcteo
id: ID:0000168

Fracture maximum load
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
definition: The stress applied to fracture a specimen.
has_obo_namespace: bcteo
has_related_synonym: Breaking strength
has_related_synonym: Fracture strength
id: ID:0000170

Fracture maximum strain
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
definition: The strain applied to fracture a specimen.
has_obo_namespace: bcteo
id: ID:0000171

Torsion modulus
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Torsion test
definition: Measure of the amount of torque that a radial shaft can sustain during its rotation in a mechanical system.
has_obo_namespace: bcteo
has_related_synonym: Torsional stiffness
id: ID:0000172

Maximum load
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
definition: Maximum stress that a material can withstand while being stretched or pulled before failing or breaking.
has_obo_namespace: bcteo
has_related_synonym: Tensile strength
has_related_synonym: Ultimate strength
has_related_synonym: Ultimate tensile strength
id: ID:0000173

Maximum strain
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Tensile test
definition: Maximum strain that a material can withstand while being stretched or pulled before failing or breaking.
has_obo_namespace: bcteo
id: ID:0000174

Other biomaterials
type: Class
subclass of: Biomaterial
has_obo_namespace: bcteo
id: ID:0000175

Polyethylene glycol
type: Class
subclass of: Polymer
definition: Polyether compound whose structure is H-(O-CH2-CH2)n-OH.
has_obo_namespace: bcteo
has_related_synonym: PEG
id: ID:0000176

Alginate
type: Class
subclass of: Gel
definition: Anionic polysaccharide distributed widely in the cell walls of brown algae, where through binding with water it forms a viscous gum. Characterized by biocompatibility and simple gelation with divalent cations such as Ca2+.
has_obo_namespace: bcteo
id: ID:0000177

Chitosan gel
type: Class
subclass of: Gel
definition: Gel obtained from chitosan, a linear polysaccharide composed of randomly distributed beta-(1-4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit), made by treating shrimp and other crustacean shells with the alkali sodium hydroxide.
has_obo_namespace: bcteo
id: ID:0000178

Gelatin
type: Class
subclass of: Gel
definition: Translucent, colorless, brittle (when dry), flavorless solid substance, derived from collagen obtained from various animal by-products.
has_obo_namespace: bcteo
id: ID:0000179

Dextran gel
type: Class
subclass of: Gel
definition: Gel based on dextran, a complex, branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 3 to 2000 kilodaltons).
has_obo_namespace: bcteo
id: ID:0000180

Polyethylene glycol gel
type: Class
subclass of: Gel
definition: Gel deriving from polyethylene glycol, produced by the interaction of ethylene oxide with water.
has_obo_namespace: bcteo
id: ID:0000181

Chitosan-alginate composite
type: Class
subclass of: Composite
definition: Material whose components are chitosan and alginate.
has_obo_namespace: bcteo
id: ID:0000182

Collagen-hydroxyapatite composite
type: Class
subclass of: Composite
definition: Material whose components are collagen and hydroxyapatite.
has_obo_namespace: bcteo
id: ID:0000183

Polycaprolactone-hydroxyapatite composite
type: Class
subclass of: Composite
definition: Material whose components are hydroxyapatite and polycaprolactone.
has_obo_namespace: bcteo
has_related_synonym: PCL-HA
id: ID:0000184

Collagen-chitosan composite
type: Class
subclass of: Composite
definition: Material whose components are chitosan and collagen.
has_obo_namespace: bcteo
id: ID:0000185

Polycaprolactone-collagen composite
type: Class
subclass of: Composite
definition: Material whose components are collagen and polycaprolactone.
has_obo_namespace: bcteo
id: ID:0000186

Other composite
type: Class
subclass of: Composite
definition: Composite material not listed among the composite materials.
has_obo_namespace: bcteo
id: ID:0000187

Polyglycolic acid
type: Class
subclass of: Polymer
definition: Polymer prepared starting from glycolic acid by means of polycondensation or ring-opening polymerization.
has_obo_namespace: bcteo
has_related_synonym: PGA
has_related_synonym: Polyglycolide
id: ID:0000188

Poloxamine-polylysine acrylate
type: Class
subclass of: Polymer
definition: Polymer for tissue engineering applications composed by polylysine, used to confer endothelial cell attachment properties to the poloxamine-based polymer, and acrylate, which makes it photo-cross-linkable.
has_obo_namespace: bcteo
has_related_synonym: PPA
id: ID:0000189

Polylactic-co-glycolic acid
type: Class
subclass of: Polymer
definition: Copolymer synthesized by means of random ring-opening co-polymerization of two different monomers, the cyclic dimers (1,4-dioxane-2,5-diones) of glycolic acid and lactic acid.
has_obo_namespace: bcteo
has_related_synonym: PLGA
id: ID:0000190

Mechanical parameter of load
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Dynamic Mechanical Analysis
definition: Dataset of physical parameters about mechanical tests performed, such as the applied intensity and velocity of strain.
has_obo_namespace: bcteo
id: ID:0000191

SEM image
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Scanning electron microscopy
definition: High-resolution image acquired from SEM technique. Morphological information about sample surface and three-dimensional structure is derived.
has_obo_namespace: bcteo
id: ID:0000192

TEM image
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Transmission electron microscopy
definition: High-resolution image of TEM acquisition. The image is formed from the interaction of the electrons transmitted through the specimen; it enables to examine fine details, even as small as a single column of atoms.
has_obo_namespace: bcteo
id: ID:0000193

X ray image
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: X-ray microtomography
definition: High-resolution 2D image from X-ray technology. Since X-rays interact with matter, it's possible to highlight specific physical entities (i.e. tissues, organs), having different X-ray adsorption properties, due to their chemico-physical nature.
has_obo_namespace: bcteo
id: ID:0000194

Excitation wavelength
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Immunohistofluorescence
definition: Wavelength of the radiation (usually coming from a laser line) used to stimulate fluorescence in the measured object. The stimulated dye will emit radiation with a particular Emission Wavelength.
has_obo_namespace: bcteo
id: ID:0000195

Thermoplasticity
type: Class
subclass of: Physical property
subclass of: Restriction
  on property: characterizes
  some values from: Ultra high molecular weight polyethylene
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone
subclass of: Restriction
  on property: characterizes
  some values from: Polyethylene glycol
subclass of: Restriction
  on property: characterizes
  some values from: Polyglycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Poly-L-lactide
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-hydroxyapatite-collagen
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-tricalcium phosphate
subclass of: Restriction
  on property: characterizes
  some values from: SPCL-Si
subclass of: Restriction
  on property: characterizes
  some values from: Collagen-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Polycaprolactone-polylactic-co-glycolic acid
subclass of: Restriction
  on property: characterizes
  some values from: Baghdadite-polycaprolactone-glass nanoparticle
definition: Material property consisting in becoming soft when heated and hard when cooled.
has_obo_namespace: bcteo
id: ID:0000196

Flexural strength
type: Class
subclass of: Mechanical property
subclass of: Restriction
  on property: derives_from
  some values from: Fracture test
definition: Mechanical parameter for brittle material, defined as a material's ability to resist deformation under load.
has_obo_namespace: bcteo
has_related_synonym: Bend strength
has_related_synonym: Fracture strength
has_related_synonym: Modulus of rupture
id: ID:0000197

SEM protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Scanning electron microscopy
definition: It first aims at fixing samples, then at dehydrating them, through a ethanols scale, and finally at coating samples with gold/palladium alloy.
has_obo_namespace: bcteo
id: ID:0000198

TEM protocol
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Transmission electron microscopy
definition: It aims at fixing samples, dehydrating and including them into resin (infiltration and embedding).
has_obo_namespace: bcteo
id: ID:0000199

Poly-L-lactide
type: Class
subclass of: Polymer
definition: Form of polylactide, having lactic acid a chiral nature, and it is the product resulting from polymerization of L,L-lactide.
has_obo_namespace: bcteo
has_related_synonym: L-lactide
has_related_synonym: PLLA
id: ID:0000200

Real-time reverse-transcription polymerase chain reaction
type: Class
subclass of: Real-time polymerase chain reaction
definition: It is a PCR real time preceded by a reverse transcription step (reverse transcription step = an RNA strand is reverse transcribed into its DNA complement using the enzyme reverse transcriptase)
has_obo_namespace: obi
has_related_synonym: qRT-PCR
id: ID:0000201

Axiom
annotated source: Real-time reverse-transcription polymerase chain reaction
annotated property: definition
annotated target: It is a PCR real time preceded by a reverse transcription step (reverse transcription step = an RNA strand is reverse transcribed into its DNA complement using the enzyme reverse transcriptase)
database_cross_reference: OBI:0000911

Extracellular matrix
type: Class
subclass of: Restriction
  on property: derives_from
  some values from: Cell seeding
subclass of: Restriction
  on property: intervenes_in
  some values from: Cellular response evaluation
definition: Network of fibers that hold cells together. It is found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. It is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
has_obo_namespace: nci_thesaurus
id: ID:0000202

Axiom
annotated source: Extracellular matrix
annotated property: definition
annotated target: Network of fibers that hold cells together. It is found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. It is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
database_cross_reference: NCIThesaurus:C13232

Growth factor
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Growth environment
definition: Extracellular signaling molecule involved in control of target cell proliferation, cell survival, and cell differentiation.
has_obo_namespace: nci_thesaurus
id: ID:0000203

Axiom
annotated source: Growth factor
annotated property: definition
annotated target: Extracellular signaling molecule involved in control of target cell proliferation, cell survival, and cell differentiation.
database_cross_reference: NCIThesaurus:C20424

Growth factor concentration
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Growth environment
definition: Measurable characteristic related to the concentration of growth factors.
has_obo_namespace: bcteo
id: ID:0000204

Growth factor species
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Growth environment
definition: It defines the organism species the growth factor comes from.
has_obo_namespace: bcteo
id: ID:0000205

Growth factor isoform
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Growth environment
definition: It defines the specific isoform of the growth factor.
has_obo_namespace: bcteo
id: ID:0000206

Sus scrofa domesticus
type: Class
subclass of: Donor
subclass of: Host
database_cross_reference: NCBITaxon:9825
has_obo_namespace: ncbi_taxonomy
id: ID:0000207

Adipose-derived stem cell
type: Class
subclass of: Cell
definition: Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell.
has_obo_namespace: bto
has_related_synonym: ADSC
id: ID:0000208

Axiom
annotated source: Adipose-derived stem cell
annotated property: definition
annotated target: Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin e.g. adipose-derived stem cell.
database_cross_reference: BTO:0005198

Embryonic stem cell
type: Class
subclass of: Cell
definition: Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent.
has_obo_namespace: nci_thesaurus
has_related_synonym: ESC
id: ID:0000209

Axiom
annotated source: Embryonic stem cell
annotated property: definition
annotated target: Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent.
database_cross_reference: NCIThesaurus:C12935

Silicon-substituted tricalcium phosphate and hydroxyapatite
type: Class
subclass of: Composite
definition: Material whose components are silicon, tricalcium phosphate and hydroxyapatite.
has_obo_namespace: bcteo
id: ID:0000210

Silk
type: Class
subclass of: Polymer
definition: A continuous protein fiber consisting primarily of fibroids. It is synthesized by a variety of insects and arachnids.
has_obo_namespace: msh
id: ID:0000211

Axiom
annotated source: Silk
annotated property: definition
annotated target: A continuous protein fiber consisting primarily of fibroids. It is synthesized by a variety of insects and arachnids.
database_cross_reference: MeSH:D047011

Titanium dioxide
type: Class
subclass of: Ceramic
definition: A titanium molecular entity that has formula O2Ti.
has_obo_namespace: chebi
id: ID:0000212

Axiom
annotated source: Titanium dioxide
annotated property: definition
annotated target: A titanium molecular entity that has formula O2Ti.
database_cross_reference: CHEBI:32234

Polycaprolactone-hydroxyapatite-collagen
type: Class
subclass of: Composite
definition: Material whose components are polycaprolactone, collagen and hydroxyapatite.
has_obo_namespace: bcteo
id: ID:0000213

Polycaprolactone-tricalcium phosphate
type: Class
subclass of: Composite
definition: Material whose components are polycaprolactone and tricalcium phosphate.
has_obo_namespace: bcteo
id: ID:0000214

SPCL-Si
type: Class
subclass of: Composite
definition: Functionalized material. A blend of corn starch with polycaprolactone used to produce three-dimensional fibre meshes scaffolds, coupled with a calcium silicate solution for the in situ functionalization with Si-OH groups.
has_obo_namespace: bcteo
id: ID:0000215
comment: From: Rodrigues AI et al. Bioactive starch-based scaffolds and human adipose stem cells are a good combination for bone tissue engineering. Acta Biomater. 2012, 8(10):3765-76.

Collagen-polylactic-co-glycolic acid
type: Class
subclass of: Composite
definition: Material whose components are collagen and polylactic-co-glycolic acid.
has_obo_namespace: bcteo
id: ID:0000216

Polycaprolactone-polylactic-co-glycolic acid
type: Class
subclass of: Composite
definition: Material whose components are polycaprolactone and polylactic-co-glycolic acid.
has_obo_namespace: bcteo
id: ID:0000217

Strontium-hardystonite-gahnite
type: Class
subclass of: Ceramic
definition: Ceramic material where Ca, Sr, Zn and Si ions have been incorporated.
has_obo_namespace: bcteo
has_related_synonym: Sr-HT-gahnite
id: ID:0000218
comment: From: Roohani-Esfahani SI et al. Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomater. 2013, 9(6):7014-24.

Baghdadite-polycaprolactone-glass nanoparticle
type: Class
subclass of: Other biomaterials
definition: Baghdadite scaffolds were coated in polycaprolactone and nanoparticles of bio-glass. The PCL coating increased the scaffolds toughness while nBG enhanced bioactivity.
has_obo_namespace: bcteo
id: ID:0000219

Periodontal ligament cell
type: Class
subclass of: Cell
definition: Fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features.
has_obo_namespace: bcteo
id: ID:0000220
comment: From: Jonsson D et al. The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodontal Res. 2011, 46(2):153-7.

Functionalization
type: Class
subclass of: Scaffold property
subclass of: Restriction
  on property: characterizes
  some values from: Baghdadite-polycaprolactone-glass nanoparticle
definition: Functionalization is employed for surface modification of industrial materials in order to achieve desired surface properties. It consists in modifying the surface of a material by bringing physical, chemical or biological characteristics different from the ones originally found on the surface of a material. The modification can be done by different methods with a view to altering a wide range of characteristics of the surface, such as: roughness, hydrophilicity, surface charge, surface energy, biocompatibility and reactivity. Coating of materials is a type of functionalization.
has_obo_namespace: bcteo
id: ID:0000221

Bioglass-collagen-phosphatidylserine
type: Class
subclass of: Composite
definition: Material whose components are bioglass, collagen and phosphatidylserine.
has_obo_namespace: bcteo
id: ID:0000222

Polyurethane
type: Class
subclass of: Polymer
definition: A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as elastomers, as coatings, as fibers and as foams.
has_obo_namespace: msh
id: ID:0000223

Axiom
annotated source: Polyurethane
annotated property: definition
annotated target: A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as elastomers, as coatings, as fibers and as foams.
database_cross_reference: MeSH:D011140

Collagen-glycosaminoglycan
type: Class
subclass of: Composite
definition: Material whose components are collagen and glycosaminoglycan
has_obo_namespace: msh
has_related_synonym: Collagen-GAG
id: ID:0000224

Axiom
annotated source: Collagen-glycosaminoglycan
annotated property: definition
annotated target: Material whose components are collagen and glycosaminoglycan
database_cross_reference: MeSH:C058506

Calcium-phosphate based ceramic-chitosan
type: Class
subclass of: Composite
definition: Material whose components are calcium-phosphate based ceramic and chitosan.
has_obo_namespace: bcteo
id: ID:0000225

Bone-derived cell
type: Class
subclass of: Cell
definition: Cell derived from bone.
has_obo_namespace: bcteo
has_related_synonym: BDC
id: ID:0000226

Umbilical cord mesenchymal stem cell
type: Class
subclass of: Cell
definition: Multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells.
has_obo_namespace: pdq
has_related_synonym: UCMSC
has_related_synonym: umbilical cord blood-derived mesenchymal stem cells
id: ID:0000227

Axiom
annotated source: Umbilical cord mesenchymal stem cell
annotated property: definition
annotated target: Multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells.
database_cross_reference: PDQ:CDR0000633689

MC3T3-E1 cell line
type: Class
subclass of: Osteoblast
definition: Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen.
has_obo_namespace: bto
id: ID:0000228

Axiom
annotated source: MC3T3-E1 cell line
annotated property: definition
annotated target: Mouse embryo/fetus calvaria fibroblasts; established from the calvaria of an embryo/fetus C57BL/6 mouse; described to differentiate to osteoblasts and to produce collagen.
database_cross_reference: BTO:0001957

Pore interconnection
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Porosity
definition: Level of connection between pores. It improves mass transport throughout the material.
has_obo_namespace: bcteo
has_related_synonym: Interpore connectivity
id: ID:0000229

Chemical functionalization
type: Class
subclass of: Functionalization
definition: Addition of functional groups/peptides/proteins/molecules/growth factors onto the surface of a material by chemical synthesis methods. Chemical functionalization is one of the main methods to obtain the desired physical and chemical properties of materials, such as hydrophilicity or bioactivation.
has_obo_namespace: bcteo
id: ID:0000230

Physical functionalization
type: Class
subclass of: Functionalization
definition: Alteration of the the surface topography of a material, producing microscale and nanoscale features in a well-controlled manner with nanocoating, film deposition, or in situ surface modifications at nanoscale level, with the aim to improve the material performances.
has_obo_namespace: bcteo
id: ID:0000231

Extraction protocol
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Primary cell culture
definition: The procedure used to obtain something from a mixture or compound by chemical or physical or mechanical means.
has_obo_namespace: efo
id: ID:0000232

Axiom
annotated source: Extraction protocol
annotated property: definition
annotated target: The procedure used to obtain something from a mixture or compound by chemical or physical or mechanical means.
database_cross_reference: EFO:0000490

Health status
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Donor
subclass of: Restriction
  on property: characterizes
  some values from: Host
definition: The condition of an organism in all aspects (e.g., functional or metabolic efficiency).
has_obo_namespace: exo
id: ID:0000233

Axiom
annotated source: Health status
annotated property: definition
annotated target: The condition of an organism in all aspects (e.g., functional or metabolic efficiency).
database_cross_reference: ExO:0000038

Seeding efficiency
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: Cell seeding
definition: The percentage of cells plated (seeded, inoculated) which attach to the surface of the culture vessel within a specified period of time. The conditions under which such a determination is made should always be stated.
has_obo_namespace: bcteo
has_related_synonym: Attachment efficiency
id: ID:0000234
comment: From: Worthington Tissue Dissociation Guide, http://www.worthington-biochem.com/tissuedissociation/glossary.html#attachment

Cytotoxicity text
type: Class
subclass of: Cellular response evaluation
definition: It determines whether a product or compound will have any toxic effect due to leachables on living cells. Generally used as a screening tool for raw materials or component products before they are put into the design of a medical device.
has_obo_namespace: bcteo
id: ID:0000235

Flow Cytometry
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell characterization
definition: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
has_obo_namespace: msh
has_related_synonym: FACS
has_related_synonym: Fluorescence-Activated Cell Sorting
id: ID:0000236

Axiom
annotated source: Flow Cytometry
annotated property: definition
annotated target: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
database_cross_reference: MeSH:D005434

NIH/3T3 cell line
type: Class
subclass of: Fibroblast
has_obo_namespace: bcteo
id: ID:0000237

Trabecular bone cell
type: Class
subclass of: Cell
definition: Cell derived from trabecular (or cancellous, or spongy) bone.
has_obo_namespace: bcteo
id: ID:0000238

Cortical bone cell
type: Class
subclass of: Cell
definition: Cell derived from cortical bone.
has_obo_namespace: bcteo
id: ID:0000239

Bone marrow stromal cell
type: Class
subclass of: Cell
definition: Primary human marrow stromal cells (MSCs) cultured from adult bone marrow (BM) mononuclear cells (MNCs).
database_cross_reference: BTO:0004122
has_obo_namespace: bcteo
has_related_synonym: BMSC
id: ID:0000240

Dental pulp stem cell
type: Class
subclass of: Cell
definition: Multipotent stem cells obtained from dental pulp.
has_obo_namespace: bcteo
has_related_synonym: DPSC
id: ID:0000241

Bone marrow stromal stem cell
type: Class
subclass of: Cell
definition: They are known to be able to transform into liver, nerve, muscle and kidney cells.
has_obo_namespace: bcteo
id: ID:0000242

Axiom
annotated source: Bone marrow stromal stem cell
annotated property: definition
annotated target: They are known to be able to transform into liver, nerve, muscle and kidney cells.
database_cross_reference: BTO:0002668

Cell characterization
type: Class
subclass of: In vitro study
definition: Procedure addressed to ensure the quality of the cells. It assesses the cell source with regard to its identity/phenotype, to the presence of other cells types, adventitious agents, endogenous agents,and molecular contaminants.
has_obo_namespace: bcteo
id: ID:0000243

MG63 cell line
type: Class
subclass of: Osteosarcoma cell
definition: Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male.
has_obo_namespace: bcteo
id: ID:0000244

Axiom
annotated source: MG63 cell line
annotated property: definition
annotated target: Homo sapiens (human) bone, osteosarcoma cell line; established from a 14 year old caucasian male.
database_cross_reference: BTO:0001596

Magnesium-calcium phosphate
type: Class
subclass of: Ceramic
definition: Biocement fabricated by using the mixed powders of magnesium oxide (MgO) and calcium dihydrogen phosphate (Ca(H2PO4)2·H2O).
has_obo_namespace: bcteo
has_related_synonym: MCPB
id: ID:0000245

Bioerosion
type: Class
subclass of: Biomaterial behaviour
definition: Process that induces a non-hydrosoluble polymer to become hydrosoluble in physiological conditions.
has_obo_namespace: bcteo
id: ID:0000246

Cell culture environment
type: Class
subclass of: Restriction
  on property: intervenes_in
  some values from: Cell seeding
definition: Experimental environment where cells are cultured onto the material. It describes all the biological parameters related to cell culture.
has_obo_namespace: bcteo
id: ID:0000247

Osteosarcoma cell
type: Class
subclass of: Cell
definition: Cell of a malignant neoplasm of the bone-forming tissues.
has_obo_namespace: bcteo
id: ID:0000248

Cytotoxicity by elution test
type: Class
subclass of: Cytotoxicity text
definition: Material is put in the culture medium for a predefined period of time. Later cells are cultured in that medium and observed under microscope to identify possible toxic effects.
has_obo_namespace: bcteo
id: ID:0000249

Direct cytotoxicity test
type: Class
subclass of: Cytotoxicity text
definition: Cells are seeded onto the material and observed under microscope to identify possible toxic effects.
has_obo_namespace: bcteo
id: ID:0000250

Biomaterial behaviour
type: Class
subclass of: Restriction
  on property: characterizes
  some values from: In vitro study
subclass of: Restriction
  on property: characterizes
  some values from: In vivo study
definition: The set of behaviors that characterize a material on its chemical-physical nature.
has_obo_namespace: bcteo
id: ID:0000251

Degradation
type: Class
subclass of: Biomaterial behaviour
definition: The reduction of a chemical compound to one less complex, as by splitting off one or more groups.
has_obo_namespace: nci_thesaurus
id: ID:0000252

Axiom
annotated source: Degradation
annotated property: definition
annotated target: The reduction of a chemical compound to one less complex, as by splitting off one or more groups.
database_cross_reference: Thesaurus:C61559

Bioreabsorption
type: Class
subclass of: Biomaterial behaviour
definition: Process of removal of a polymer or its degradation products through the cellular activity (phagocytosis).
has_obo_namespace: bcteo
id: ID:0000253